Innovative method and technologies have the potential to speed-up therapy development and derisking the development process in an early stage. For example, through rapid screening methods, innovative data mining, and a better understanding of complex disease mechanisms, the number of substances and biological targets to be investigated have strongly increased. Innovative technologies, including human stem cell models like organoids and organs-on-a-chip, have the potential to evaluate the feasbility of therapy lead earlier in the development process, due to significantly enhanced predictive value. Innovative methodologies, including integrative mathematical modeling, trial methodology, real-world data and learning healthcare systems can speed-up clinical studies and implementation in the clinical practice. The field faces the challenge of implementation including further development, regulatory acceptance, often including qualification or validation, and adoption in therapy development practice of these enabling methods and technologies.
Discover and access tools, data, protocols, and other related resources for multi-omics analyses in one convenient place: Multi-omics Toolbox (MOTBX) – An open access web resource to help expedite translational research