Innovative screening methods, such as high-throughput screening, organ-on-a-chip and AI-driven simulations, are accelerating drug development by identifying promising compounds more quickly and accurately. These technologies reduce reliance on traditional animal testing and improve predictions of human responses. However, challenges such as high cost, technical complexity and regulatory acceptance must be addressed to fully integrate these methods into mainstream drug discovery.
NAM: New Approach Methods
- For guidance in validation of NAMs: platform launched by ZonMw: https://namnavigator.eu/
- FDA Roadmap to Reducing Animal Testing in Preclinical Safety Studie
- EMA - Regulatory acceptance of 3R (replacement, reduction, refinement) testing approaches